On the history of cardiology in Tomsk: Focus on management of acute myocardial infarction

The article is devoted to the history of cardiology in Tomsk. The authors show that Tomsk cardiology stems from the famous Siberian therapeutic schools of Professors M.G. Kurlov, D.D. Yablokov, and B.M. Shershevsky. The birth of modern cardiology in Tomsk is attributed to the organization of the Siberian branch of the All-Union Cardiology Scientific Center of the USSR Academy of Medical Sciences in 1980. The achievements of Tomsk cardiology are presented using the example of the management of acute myocardial infarction (AMI). The article demonstrates that the implementation of cutting-edge methods for AMI diagnostics and treatment, including R&D results achieved by the institute's researchers, enabled a significant reduction of hospital mortality rate, from 20% to 8%. Particular attention is given to the pharmacoinvasive strategy of AMI treatment.

1. Borodulin VI. History of Medicine of Russia Clinic of internal diseases in the second half of the XIX - first half of the XX century. Moscow: "MEDpress-Inform"; 2011:144 (In Russ.).

2. The origins of the Siberian Therapeutic School. The Department of the Faculty Therapeutic Clinic of the Siberian State Medical University is 120 years old; еdit. by Karpov R.S. Tomsk; 2010:139 (In Russ.).

3. Logvinov S.V., Malinovskaya I.S., Nekrylov S.A. Pages of the history of Medical (medical) Faculty of the Siberian State Medical University. Tomsk: Ivan Fedorov; 2008:283 (In Russ.).

4. Eckardt E.V, Bodrova T.N., Tetenev F.F., Rodionova O.V., Ivanova N.G. An alteration of the parameters of respiratory biomechanics and high-resolution computed tomography in chronic obstructive pulmonary disease. Bulletin of Siberian Мedidne. 2011;1:168-173 (In Russ.).

5. Tetenev F.F. History of the Department of Internal Diseases Propedeu-tics of SSMU. Bulletin of Siberian Мedicine. 2015;14(4):125-133 (In Russ.). DOI: 10.20538/1682-0363-2015-4-125-133.

6. Chazov E.I. Atherosclerosis. Round table discussion. Therapeutic Archive. 1990;62(8):7-21 (In Russ.).

7. Steinhardt Yu.N. History of the Department of Internal Medicine Propaedeutics (In Russ.). www.ssmu.ru/obrazovanie/depatments/proped_det_bol/histery/

8. Karpov R.S. Cardiology in Siberia: succession of generations. Siberian Medical Journal. 2015;30(3):73-83 (In Russ.). DOI: 10.29001/2073-8552-2015-30-3-78-83.

9. Rudnikovich О.М., Trubacheva I.A. Heart community. 30 years Research Institute of Cardiology. Tomsk: Tomsk Рotential; 2010:141 (In Russ.).

10. Negovsky VA. Basics of resuscitation; уd. 3, add. Tashkent: Medicine of UzSSR; 1977:580 (In Russ.).

11. Chazov E.I. Cardiology in the USSR. Moscow: Medicine; 1982:288 (In Russ.).

12. Pekarsky V., Gimrich E., Zelenov V., Savenkov G., Kuhn V., Markov V. Treatment of patients with tachycardias and arrhythmias from acute myocardial infarction by electrical pacing. Japanese Heart Journal. 1982;23(12):268-270.

13. Markov V.A., Tyukalova L.I., Goreva N.A., Shteyngardt Yu.N. Diagnose latent heart failure by measuring oxygen tension in arterialized capillary blood and tissues. Medical Abstract Journal. 1979;XV(8):1020 (In Russ.).

14. Markov VA, Steinhardt Yu.N., Insel T.N. The acid-base state of the blood in heart failure patients treated with certain drugs. Cardiology. 1978;1:74-77 (In Russ.).

15. History of the Russian Society of Cardiology. http://scardio.ru.

16. Shteyngardt Yu.N., Tyukalova L.I., Kun V.I., Markov V.A., Tsymbalyuk V.P. State of peripheral hemodynamics and the effect on it of certain drugs in left ventricular failure in patients with chronic ischemic heart disease. Cardiology. 1983;3:91-95 (In Russ.).

17. Karpov R.S. To the Research Institute of Cardiology of the Tomsk Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences for 20 years (1980-2000). Tomsk: STT; 2005:125 (In Russ.).

18. Vasiltsev Ya.S., Karpov R.S., Markov V.A., Varvarenko V.I., Kun V.I., Maksimov I.V. et al. Influence of intracoronary infusion syndrome and verapamil treatment on the size of the affected area in patients with myocardial infarction. Cardiology. 1986;8:58-62 (In Russ.).

19. Markov V.A., Varvarenko V.I., Kun V.I. Comparison of intracoronary and intravenous methods of thrombolytic therapy with streptokinase in patients with acute myocardial infarction. Cardiology. 1988;5:20-23 (In Russ.).

20. Stolyarov V.A., Markov V.A., Varvarenko V.I., Chernyavskaya L.I., Karpov R.S. The relationship between systemic fibrinolytic state and the achievement of coronary reperfusion in thrombolytic therapy with streptokinase of patients with acute myocardial infarction. Cardiology. 1989;9:92-94 (In Russ.).

21. Markov V.A., Varvarenko V.I., Kun V.I., Maksimov I.V. An alteration of the contractile function of the left ventricle under the influence of thrombolytic reperfusion of the coronary arteries in acute myocardial infarction. Cardiology. 1990;10:12-15 (In Russ.).

22. Karpov R.S., Markov V.A., Danilenko A.M., Varvarenko V.I., Zakharova R.M., Dzhavadov K.Y. et al. Efficiency of thrombolytic therapy acute myocardial infarction at the prehospital stage. Cardiology. 1992;32(9-10):23-25 (In Russ.).

23. Markov V.A., Vyshlov E.V., Panfilova E.V., Maksimov I.V. Comparison of the effectiveness of streptokinase with the bolus and drip method of administration in patients with acute myocardial infarction. Cardiology. 2002;9:26-29 (In Russ.).

24. Markov V.A., Vyshlov E.V. Thrombolytic therapy at myocardium infarction. Tomsk: STT; 2011:147 (In Russ.).

25. Maksimov I.V., Repin A.N., Markov V.A., Shikankov V.A., Varvarenko VI. Evaluation of the cardioprotective effect of emoxipin during thrombolytic reperfusion. Cardiology. 1994;34(3-4):4-7 (In Russ.).

26. Markov V.A., Minazutdinov S.M., Maksimov I.V., Repin A.N., Shikankov V.A., Varvarenko V.I. et al. The effectiveness of verapamil in reducing reperfusion injury in coronary thrombolysis in patients with acute myocardial infarction. Clinical Pharmacology and Therapy. 1997;1:30-31 (In Russ.).

27. Markov V.A., Kun V.I., Varvarenko V.I., Maksimov I.V. Thrombolytic therapy of the acute stage of myocardial infarction by the method of intravenous rapid injection of an average dose of streptokinase (Guidelines) of the RSFSR; by edit. R.S. Karpov. Moscow: Ministry of Health; 1987:13 (In Russ.).

28. Markov V.A., Kun V.I., Maksimov I.V., Varvarenko V.I., Danilenko A.M., Stolyarov V.A. et al. Thrombolytic therapy on the myocardin tip infarction before the clinical phase. Modern Medicine (Sofia, Bulgaria). 1990;41(3):13-18 (In Bulg.).

29. Chazov E.I. Atherosclerosis. Round table discussion. Therapeutic Archive. 1990;62(8):7-21 (In Russ.).

30. Markov V.A., Balakhonova M.V., Repin A.N., Demyanov S.V. The effect of thrombolytic therapy on mortality in patients with acute myocardial infarction with true cardiogenic shock. Cardiovascular Therapy and Prevention. 2004;3(4):44-50 (In Russ.).

31. Markov V.A., Repin A.N., Demyanov S.V., Balakhonova M.V., Krylov A.L. Emergency balloon angioplasty in the treatment of cardiogenic shock in patients with acute myocardial infarction. Bulletin of Siberian Medicine. 2003;4:45-51 (In Russ.).

32. Ryabova T.R., Sokolov A.A., Dudko V.A., Ryabov V.V., Markov V.A. Dynamics of structural and functional parameters of the left ventricle in patients with acute myocardial infarction. Cardiology. 2002;9:30-34 (In Russ.).

33. Ryabov V.V., Kirgizova M.A., Markov V.A. Heart-type fatty acid binding protein-based express test in the diagnostic of acute myocardial infarction. Russian Cardiology Journal. 2014;106(2):84-88 (In Russ.).

34. Ryabov V.V., Markov V.A., Poponina Yu.S., Suslova T.E., Krylov A.L., Popov S.V. et al. Autologous mononuclear cells of the bone marrow in the processes of regenerative regeneration in acute myocardial infarction. Cell Technology in Biology and Medicine. 2005;3:30-34 (In Russ.).

35. Kirgizova M.A., Ryabov V.V., Suslova T.E., Markov V.A. Long-term clinical efficacy of bone marrow autologous mononuclear cell transplantation in acute myocardial infarction with ST-elevation. Cardiology: News, Views, Education. 2017;1:28-34 (In Russ.).

36. Vyshlov E.V., Panfilova E.V, Stolyarov V.A., Markov V.A. Effect of cy-clopidine and aspirin on ADP-induced platelet aggregation in patients with acute myocardial infarction. Clinical Pharmacology and Therapy. 1998;2:49-50 (In Russ.).

37. Poponina T.M., Antipov S.I., Starokha E.A. Comparison of the effectiveness of the administration of unfractionated heparin in the treatment of acute coronary syndrome without ST-elevation. Siberian Medical Journal. 2001;9:36-38 (In Russ.).

38. Pekarsky V.V., Chernyavsky A.M., Markov V.A., Maksimov I.V., Repin A.N., Chernov VI. Thrombolytic therapy and surgical revascularization in the treatment of acute myocardial infarction. Thoracic and Cardiovascular Surgery. 1995;3:42-46 (In Russ.).

39. Vyshlov E.V., Sevastyanova D.S., Krylov A.L., Markov V.A. Primary angioplasty and pharmaco-invasive reperfusion in myocardial infarction: impact on clinical outcomes and no-reflow phenomenon. Cardiovascular Therapy and Prevention. 2015:14(1):17-22 (In Russ.).

40. Markov V.A., Vyshlov E.V., Karpov R.S. Coronary reperfusion in ST- elevation myocardial infarction: problems and solutions. Russian Journal of Cardiology. 2015;1(117):53-58 (In Russ.). DOI: 10.15829/1560-4071-2015-1-53-58.

41. Karpov R.S. The true history of the Tomsk cardiac center in persons, facts, interviews and documents, written by direct participants and witnesses of the events (1980-2010). Tomsk: STT; 2012:300 (In Russ.).

42. Markov V.A., Duplyakov D.V., Konstantinov S.L., Klein G.V., Aksentyev S.B., Platonov D.Yu. et al. Fortelisin® versus Metalyse® in ST-segment elevation myocardial infarction: results of a multicenter randomized study FRIDOM 1. Kardiologicheskii Vestnik. 2017;14(3):52-59 (In Russ.).

43. Markov V.A., Ryabov V.V., Vyshlov E.V, Ryabova T.R., Shurupov V.S., Oyunarov E.O. et al. Postinfarction heart remodeling of acute myocardial infarction and pharmakoinvasive reperfusion and enhanced external counterpulsation. Tomsk: STT; 2015:244 (In Russ.).

44. Chazov E.I. Emergency conditions in cardiology. Round table discussion. Therapeutic Archive. 1994;66:16-17 (In Russ.).

45. Alekseeva Ya.V., Vyshlov E.V, Ryabov V.V., Mochula O.V., Usov VYu., Markov V.A. et al. Phenomenons of microvascular injury in primary myocardial infarction with ST-segment elevation. Kardiologicheskii Vestnik. 2019;2(14):54-60 (In Russ.).

46. Mendrina G.I., Bova P.A. To the history of the periodical medical press in Siberia. Siberian Medical Journal. 1996;1:5-7 (In Russ.).

47. Karpov R.S., Dudko V.A. Materials of the Second Congress of Siberian Doctors. Tomsk: Siberian Publishing House; 2001:480 (In Russ.).