Associations of the prevalence of atherogenic lipoprotein fractions and vital exhaustion in men of open population

Aim. To elucidate the associations of the prevalence of hypertriglyceridemia (HTG) and high-density lipoprotein hypocholesterolemia (hypo-HDL-ChE) with the levels of vital exhaustion in an unorganized population of 25-64-year-old men in the moderately urbanized city of Western Siberia.

Material and Methods. A single-stage epidemiological study was conducted in an unorganized population of the moderately urbanized city of Western Siberia (the model of Tyumen). A representative sample of 1,000 people (25-64-year-old men in four decades of life) was formed based on the electoral lists of the citizens with the response rate of 85.0%. Cardiological screening data were used to analyze the levels of triglycerides and HDL cholesterol. The results of vital exhaustion assessment (low, moderate, or high level) were evaluated by the psychosocial methods of the WHO MONICA-MOPSY program. Low level of vital exhaustion was considered a physiologically normal state.

Results. In an open population of men residing in the moderately urbanized city of Western Siberia, the average levels of triglycerides and HDL cholesterol were examined in a wide diapason of ages ranging from 25 to 64 years. The prevalence rates of HTG and hypo-HDL-ChE were 10.5% and 4.3%, respectively. The study showed that the indicators did not form a consistent age trend in the population. The age-standardized indicator of vital exhaustion in men of the open population was 54.5% where 15.9% and 38.6% of men had high and moderate levels of vital exhaustion, respectively. The rate of high level of vital exhaustion at the age of 55-64 years exceeded the corresponding rate in the younger age categories by 2-4 times. In the open population of men aged 25-64, HTG was predominant in groups with the low levels of vital exhaustion whereas hypo-HDL-ChE was predominant in the groups with moderate vital exhaustion.

Conclusions. The development and organization of preventive programs in the conditions of Siberian cities with a moderate degree of urbanization may be based on the data obtained from the single-stage epidemiological study characterizing the prevalence of dyslipidemia in the unorganized urban population of the Tyumen model and its associations with the levels of vital exhaustion.

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