Carotid atherosclerosis, arterial hypertension, and left ventricular remodeling in men working on a rotational basis in the Far North
https://doi.org/10.29001/2073-8552-2020-35-1-159-166
Abstract
Purpose. To estimate relationships of the atherosclerotic alterations in the walls of common carotid arteries (CCA) with the left ventricular (LV) remodeling and office blood pressure (BP) in men working on a rotational basis in the Far North.
Material and Methods. The study was performed at the premises of the Healthcare Unit of Gazprom Dobycha Yamburg OOO (68° N) in 2010–2012. A total of 424 men aged 30–59 years were randomly selected among people (n = 1708) who worked on a rotational basis in the Yamburg settlement (68° N) and passed a preventive medical examination. Patients were assigned to two groups according to BP level: group 1 included 294 men with hypertension stage 1–2 (BP > 140/90 mmHg); group 2 included 130 men with BP < 140/90 mmHg. The groups did not differ in regard to age, the total duration of employment in the Far North, and the length of rotational shiftwork. The following procedures were performed: ultrasound examination of CCA with a calculation of intima-media complex thickness (IMCT) and detection of the presence (or absence) of the atherosclerotic plaques (ASP) with stenosis grading using North American Symptomatic Carotid Endarterectomy Trial (NASCET) method; echocardiography with calculation of LV myocardial mass (LVMM), LVMM index, and LV geometric model.
Results. IMCT and the frequency of ASP detection in CCA were weakly associated with the level of office BP. Analysis of the regression models in individuals with normal and elevated BP also revealed weak associations of the values of IMCT and LVMM, LVMM index, LV wall thickness, and LV diastolic volume explaining only 10% and 8% of changes in this parameter. Hypothesis about the relationships between the frequencies of ASP detection and LV remodeling types was not confirmed. However, the frequency of ASP detection was significantly associated with LV concentric remodeling type in normotensive patients of group 2.
Conclusion. Atherosclerotic alterations in the carotid artery and cardiac remodeling did not progress simultaneously and were weakly associated with office BP in men working on a rotational basis in the Far North. The frequency of detection of ASP in CCA was significantly associated with the concentric type of LV remodeling only in men with normal office BP, which certainly requires more detailed study in follow-up works.
Material and Methods. The study was performed at the premises of the Healthcare Unit of Gazprom Dobycha Yamburg OOO (68° N) in 2010–2012. A total of 424 men aged 30–59 years were randomly selected among people (n = 1708) who worked on a rotational basis in the Yamburg settlement (68° N) and passed a preventive medical examination. Patients were assigned to two groups according to BP level: group 1 included 294 men with hypertension stage 1–2 (BP > 140/90 mmHg); group 2 included 130 men with BP < 140/90 mmHg. The groups did not differ in regard to age, the total duration of employment in the Far North, and the length of rotational shiftwork. The following procedures were performed: ultrasound examination of CCA with a calculation of intima-media complex thickness (IMCT) and detection of the presence (or absence) of the atherosclerotic plaques (ASP) with stenosis grading using North American Symptomatic Carotid Endarterectomy Trial (NASCET) method; echocardiography with calculation of LV myocardial mass (LVMM), LVMM index, and LV geometric model.
Results. IMCT and the frequency of ASP detection in CCA were weakly associated with the level of office BP. Analysis of the regression models in individuals with normal and elevated BP also revealed weak associations of the values of IMCT and LVMM, LVMM index, LV wall thickness, and LV diastolic volume explaining only 10% and 8% of changes in this parameter. Hypothesis about the relationships between the frequencies of ASP detection and LV remodeling types was not confirmed. However, the frequency of ASP detection was significantly associated with LV concentric remodeling type in normotensive patients of group 2.
Conclusion. Atherosclerotic alterations in the carotid artery and cardiac remodeling did not progress simultaneously and were weakly associated with office BP in men working on a rotational basis in the Far North. The frequency of detection of ASP in CCA was significantly associated with the concentric type of LV remodeling only in men with normal office BP, which certainly requires more detailed study in follow-up works.
About the Authors
A. S. Vetoshkin
Healthcare Unit of Gazprom Dobycha Yamburg OOO,
Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. of Sci. (Med.), Functional and Ultrasound Diagnostics Physician; Senior Research Scientist, Hypertension and Coronary Insufficiency Department, Scientific Division of Clinical Cardiology
32A, Tayozhnaya str., Yamal-Nenets Autonomous District, Noviy Urengoy, 629305, Russian Federation
111, Melnikaite str., Tyumen, 625026, Russian Federation
N. P. Shurkevich
Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. Sci. (Med.), Leading Research Scientist, Arterial Hypertension and Coronary Insufficiency Department, Scientific Division of Clinical Cardiology
111, Melnikaite str., Tyumen, 625026, Russian Federation
L. I. Gapon
Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Head of Scientific Division of Clinical Cardiology
111, Melnikaite str., Tyumen, 625026, Russian Federation
A. A. Simonyan
Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Resident Physician, Hypertension and Coronary Insufficiency Department, Scientific Division of Clinical Cardiology
111, Melnikaite str., Tyumen, 625026, Russian Federation
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Review
For citations:
Vetoshkin A.S., Shurkevich N.P., Gapon L.I., Simonyan A.A. Carotid atherosclerosis, arterial hypertension, and left ventricular remodeling in men working on a rotational basis in the Far North. Siberian Journal of Clinical and Experimental Medicine. 2020;35(1):159-166. (In Russ.) https://doi.org/10.29001/2073-8552-2020-35-1-159-166
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