Abdominal obesity and other components of metabolic syndrome among the young population of Novosibirsk
https://doi.org/10.29001/2073-8552-2020-35-1-167-176
Abstract
Objective. To study the prevalence of abdominal obesity (AO) and metabolic syndrome (MS) components among young adults in the city of Novosibirsk.
Material and Methods. A cross-sectional study of the young population of Novosibirsk was performed in 2013–2017. A representative sample comprised 1,512 people aged 25–44 years. The study included 1,449 people (45.6% men) based on the presence of all criteria required to perform the analysis according to the goal. The following age groups were assigned for the study: group 1 comprised 25–34-year-old individuals; group 2 included 35–44-year-olds. According to the recommendations for diagnosis and treatment of MS (RSC, 2009), AO was detected when participants had a waist circumference greater than 94/80 cm in men/women; hypertriglyceridemia (hyper-TG) when triglycerides (TG) were ≥ 1.7 mmol/L; low-density lipoprotein (LDL) hypercholesterolemia (hyper-LDL) when LDL cholesterol was > 3.0 mmol/L; highdensity lipoprotein (LDL) hypocholesterolemia (hypo-HDL) when HDL cholesterol was < 1.0/1.2 mmol/L in men/women; hypertension (AH130/85) when blood pressure (BP) was ≥ 130/85 mmHg; and fasting hyperglycemia (hyper-Gl) when fasting plasma glucose was ≥ 6.1 mmol/L.
Results. The prevalence rates of AO were 43.0% in men and 42.0% in women (p = 0.679); AН130/85 rates were 48.6% in men and 20.9% in women (p < 0.0001); hyper-TG rates were 24.5% in men and 9.9% in women (p < 0.0001); hypo-HDL rates were 20.0% in men and 24.7% in women (p = 0.033); hyper-LDL rates were 60.3% in men and 50.3% in women (p = 0.0002); and hyper-Gl rates were 32.4% in men and 15.7% in women (p < 0.0001). An increase in age was associated with a significant increase in the frequencies of AO, AH130/85, hyper-LDL, and hyper-Gl in both men and women (age group 2 relative to group 1). A tendency to an increase in hyper-TG was observed in women. In terms of prevalence, men had the highest prevalence rate of hyper-LDL followed by AH130/85 (the second-highest rate) and AO (the third-highest rate). Women had the highest prevalence rate of hyper-LDL, followed by AO (the second-highest rate). According to the results of univariate analysis, AO was associated with all components of MS in both men and women. The frequency of MS (RSC, 2009) was 32.0% in men and 22.2% in women (p < 0.0001).
Conclusions. Data obtained demonstrate the prognostically unfavorable situation in regard to cardiovascular pathology among young adults of Novosibirsk (especially among men), which requires prompt action to timely detect and correct the modifiable risk factors of this nosological entity.
Material and Methods. A cross-sectional study of the young population of Novosibirsk was performed in 2013–2017. A representative sample comprised 1,512 people aged 25–44 years. The study included 1,449 people (45.6% men) based on the presence of all criteria required to perform the analysis according to the goal. The following age groups were assigned for the study: group 1 comprised 25–34-year-old individuals; group 2 included 35–44-year-olds. According to the recommendations for diagnosis and treatment of MS (RSC, 2009), AO was detected when participants had a waist circumference greater than 94/80 cm in men/women; hypertriglyceridemia (hyper-TG) when triglycerides (TG) were ≥ 1.7 mmol/L; low-density lipoprotein (LDL) hypercholesterolemia (hyper-LDL) when LDL cholesterol was > 3.0 mmol/L; highdensity lipoprotein (LDL) hypocholesterolemia (hypo-HDL) when HDL cholesterol was < 1.0/1.2 mmol/L in men/women; hypertension (AH130/85) when blood pressure (BP) was ≥ 130/85 mmHg; and fasting hyperglycemia (hyper-Gl) when fasting plasma glucose was ≥ 6.1 mmol/L.
Results. The prevalence rates of AO were 43.0% in men and 42.0% in women (p = 0.679); AН130/85 rates were 48.6% in men and 20.9% in women (p < 0.0001); hyper-TG rates were 24.5% in men and 9.9% in women (p < 0.0001); hypo-HDL rates were 20.0% in men and 24.7% in women (p = 0.033); hyper-LDL rates were 60.3% in men and 50.3% in women (p = 0.0002); and hyper-Gl rates were 32.4% in men and 15.7% in women (p < 0.0001). An increase in age was associated with a significant increase in the frequencies of AO, AH130/85, hyper-LDL, and hyper-Gl in both men and women (age group 2 relative to group 1). A tendency to an increase in hyper-TG was observed in women. In terms of prevalence, men had the highest prevalence rate of hyper-LDL followed by AH130/85 (the second-highest rate) and AO (the third-highest rate). Women had the highest prevalence rate of hyper-LDL, followed by AO (the second-highest rate). According to the results of univariate analysis, AO was associated with all components of MS in both men and women. The frequency of MS (RSC, 2009) was 32.0% in men and 22.2% in women (p < 0.0001).
Conclusions. Data obtained demonstrate the prognostically unfavorable situation in regard to cardiovascular pathology among young adults of Novosibirsk (especially among men), which requires prompt action to timely detect and correct the modifiable risk factors of this nosological entity.
About the Authors
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine, Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. Sci. (Med.), Corresponding Member of the Russian Academy of Sciences, Acting Head
175/1, B. Bogatkova str., Novosibirsk, 630089, Russian Federation
V. I. Oblaukhova
Research Institute of Internal and Preventive Medicine, Russian Academy of Sciences
Russian Federation
Postgraduate
175/1, B. Bogatkova str., Novosibirsk, 630089, Russian Federation
Russian Federation
Postgraduate
175/1, B. Bogatkova str., Novosibirsk, 630089, Russian Federation
D. V. Denisova
Research Institute of Internal and Preventive Medicine, Russian Academy of Sciences
Russian Federation
Russian Federation
Dr. Sci. (Med.), Leading Research Scientist, Laboratory of Preventive Medicine
175/1, B. Bogatkova str., Novosibirsk, 630089, Russian Federation
N. A. Kovalkova
Research Institute of Internal and Preventive Medicine, Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. Sci. (Med.), Head of Research and Innovation Department
175/1, B. Bogatkova str., Novosibirsk, 630089, Russian Federation
References
1. Patel K.K., Taksler G.B., Hu B., Rothberg M.B. Prevalence of elevated cardiovascular risks in young adults: A cross-sectional analysis of national health and nutrition examination surveys. Annals of Internal Medicine. 2017;166(12):876–882. DOI: 10.7326/m16-2052.
2. Recommendations of experts of Russian Scientific Society of Cardiologists on diagnosis and treatment of metabolic syndrome (2nd revision). Prakticheskaya meditsina. 2010;5(44):81–101 (In Russ.).
3. Singh M., Benencia F. Inflammatory processes in obesity: focus on endothelial dysfunction and the role of adipokines as inflammatory mediators. Int. Rev. Immunol. 2019;38(4):157–171. DOI: 10.1080/08830185.2019.1638921.
4. Monitoring of cardiovascular morbidity, mortality and their risk factors in different regions of the world (WHO MONICA project) in two volumes; edit. by Acad. Nikitin Yu.P. Novosibirsk: Acad. Publishing House GEO; 2016:699 (In Russ.).
5. Ryden L., Standl E., Bartnik M., den Berghe G.V., Betteridge J., de Boer M. et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text. The Task Force on Diabetes and Cardiovascular Diseasesof the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur. Heart J. Suppl. 2007;9(C1):C3–C74. DOI:10.1093/eurheartj/ehl261.
6. Pasternak R. National Cholesterol Education Program (NCEP) Guidelines on the Detection, Evaluation and Treatment of Elevated Cholesterol in Adults: Adult Treatment Panel III (ATP III). ACC Cur. J. Rev.
7. 2002;11(4):37–45. DOI: 10.1016/s1062-1458(02)00670-0.
8. Alberti K.G.M.M., Zimmet P., Shaw J. Metabolic syndrome – a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabetic Med. 2006;23(5):469–480. DOI: 10.1111/j.1464-5491.2006.01858.x.
9. Alberti K.G.M.M., Eckel R.H., Grundy S.M., Zimmet P., Cleeman J., Donato K. et al. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–1645. DOI: 10.1161/circulationaha.109.192644.
10. Disability and social status of disabled people in Russia; еdit. T.M. Malyova. Moscow: Delo; 2017:256 (In Russ.).
11. Piepoli M.F., Hoes A.W., Agewall S., Albus C., Brotons C., Catapano A.L. et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016;252:207–274. DOI: 10.1016/j.atherosclerosis.2016.05.037.
12. Muromtseva G.A., Kontsevaya A.V., Konstantinov V.V., Artamonova G.V., Gatagonova T.M., Duplyakov D.V. et al. The prevalence of non-infectious diseases risk factors in Russian population in 2012–2013 years. The results of ECVD-RF. Cardiovascular Therapy and Prevention. 2014;13(6):4–11. DOI: 10.15829/1728-8800-2014-6-4-11 (In Russ.).
13. Gruzdeva O.V., Akbasheva O.E., Dyleva Y.A., Antonova L.V., Matveeva V.G., Uchasova E.G. et al. Adipokine and сytokine рrofiles of еpicardial and subcutaneous adipose tissue in patients with coronary heart disease. Bull. Exp. Biol. Med. 2017;163(5):608–611 . DOI: 10.1007/s10517-017-3860-5.
14. Uchasova E.G., Gruzdeva O.V., Dyleva Yu.A., Belik E.V., Barbarash O.L. The role of immune cells in the development of adipose tissue dysfunction in cardiovascular diseases. Russian Journal of Cardiology. 2019;(4):92–98 (In Russ.). DOI: 10.15829/1560-4071-2019-4-92-98.
15. Alexopoulos N., Katritsis D., Raggi P. Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis. Atherosclerosis. 2014;233(1):104–112. DOI: 10.1016/j.atherosclerosis.2013.12.023.
16. Balanova Y.A., Shalnova S.A., Imaeva A.E., Kapustina A.V., Muromtseva G.A., Evstifeeva S.E. et al. Prevalence, Awareness, Treatment and Control of Hypertension in Russian Federation (Data of Observational ESSE-RF-2 Study). Rational Pharmacotherapy in Cardiology. 2019;15(4):450–466 (In Russ.). DOI: 10.20996/1819-6446-2019-15-4-450-466.
17. Potočnjak I., Bodrožić-Džakić T., Šmit I., Trbušić M., Milošević M., Degoricija V. Gender-associated differences in acute heart failure patients presenting to emergency department. Acta Clinica Croatica. 2015;54(3):257–265.
18. Kes V.B., Jurašić M.J., Zavoreo I., Lisak M., Jelec V., Matovina L.Z. Age and gender differences in acute stroke hospital patients. Acta Clinica Croatica. 2016;55(1):69–78.
19. Oganov R.G., Maslennikova G.Ya. Gender differences in cardiovascular pathology. Cardiovascular Therapy and Prevention. 2012;11(4):101–104 (In Russ.).
20. Pechère-Bertschi A., Burnier M. Female sex hormones, salt, and blood pressure regulation. Am. J. Hypertens. 2004;17(10):994–1001. DOI: 10.1016/j.amjhyper.2004.08.009.
21. Kuntsevich A.K., Mustafina S.V., Verevkin E.G., Denisova D.V., Malyutina S.K., Batluk T.I. et al. Association of dietary intake with a risk factor of atherosclerosis – abdominal obesity among women of Novosibirsk. Atherosclerosis. 2017;13(4):25–31 (In Russ.). DOI: 10.15372/ATER20170404.
22. Di Pilla M., Bruno R.M., Taddei S., Virdis A. Gender differences in the relationships between psychosocial factors and hypertension. Maturitas. 2016;93:58–64. DOI: 10.1016/j.maturitas.2016.06.003.
23. Balanova Y.A., Shalnova S.A., Deev A.D., Imaeva A.E., Kontsevaya A.V., Muromtseva G.A. et al. Obesity in Russian population – prevalence and association with the non-communicable diseases risk factors. Russian Journal of Cardiology. 2018;(6):123–130 (In Russ.). DOI: 10.15829/1560-4071-2018-6-123-130.
24. Gierach M., Gierach J., Ewertowska M., Arndt A., Junik R. Correlation between body mass index and waist circumference in patients with metabolic syndrome. ISRN Endocrinology. 2014:514589. DOI: 10.1155/2014/514589.
25. Mattsson N., Rönnemaa T., Juonala M., Viikari J., Raitakari O. The prevalence of the metabolic syndrome in young adults. The Cardiovascular Risk in Young Finns Study. J. Int. Med. 2007;261(2):159–169. DOI: 10.1111/j.1365 2796.2006.01752.x.
26. Vernay M., Salanave B., de Peretti C., Druet C., Malon A., Deschamps V. et al. Metabolic syndrome and socioeconomic status in France: The French Nutrition and Health Survey (ENNS, 2006–2007). Int. J. Public. Health. 2013;58(6):855–864. DOI: 10.1007/s00038-013-0501-2.
27. Zuo H., Shi Z., Hu X., Wu M., Guo Z., Hussain A. Prevalence of metabolic syndrome and factors associated with its components in Chinese adults. Metabolism. 2009;58(8):1102–1108. DOI: 10.1016/j.metabol.2009.04.008.
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For citations:
Ragino Yu.I., Oblaukhova V.I., Denisova D.V., Kovalkova N.A. Abdominal obesity and other components of metabolic syndrome among the young population of Novosibirsk. Siberian Journal of Clinical and Experimental Medicine. 2020;35(1):167-176. (In Russ.) https://doi.org/10.29001/2073-8552-2020-35-1-167-176
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