EXPERIMENTAL STUDY OF POLYCAPROLACTONE VASCULAR GRAFT FOR BLOOD VESSEL REGENERATION
https://doi.org/10.29001/2073-8552-2016-31-1-53-57
Abstract
The polycaprolactone (PCL) vascular graft for tissue regeneration was evaluated in the longterm in vivo study. The grafts were fabricated by electrospinning with the further morphological assessment and mechanical tests. Grafts were implanted into rat abdominal aortas for 2 weeks, 1 and 10 months to evaluate the formation of blood vessels and graft biocompatibility. PCL grafts had a highly porous structure. Mechanical properties of the grafts differed from those of native vessels; however, grafts were able to withstand the mechanical stress created by a blood flow. Implanted grafts were infiltrated by the host cells. Thus, PCL grafts are biocompatible and can be used as temporary vascular prostheses.
About the Authors
V. V. Sevostyanova
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
A. V. Mironov
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
T. V. Glushkova
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
A. Yu. Burago
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
V. G. Matveeva
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
L. V. Antonova
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
Yu. A. Kudryavtseva
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
A. M. Seifalian
Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Science, University College London (UCL), London, England, UK and NanoRegMed Ltd, London
United Kingdom
United Kingdom
O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
L. S. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Russian Federation
Russian Federation
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Review
For citations:
Sevostyanova V.V., Mironov A.V., Glushkova T.V., Burago A.Yu., Matveeva V.G., Antonova L.V., Kudryavtseva Yu.A., Seifalian A.M., Barbarash O.L., Barbarash L.S. EXPERIMENTAL STUDY OF POLYCAPROLACTONE VASCULAR GRAFT FOR BLOOD VESSEL REGENERATION. Siberian Journal of Clinical and Experimental Medicine. 2016;31(1):53-57. (In Russ.) https://doi.org/10.29001/2073-8552-2016-31-1-53-57
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