RADIONUCLIDE ASSESSMENT OF MYOCARDIAL FLOW RESERVE IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE
https://doi.org/10.29001/2073-8552-2016-31-2-31-34
Abstract
The aim of the study was to develop the methodology for collecting and processing the scintigraphic data to determine myocardial reserve on gamma camera with a solid state cadmium zinc tellurium detectors. Sixteen patients with coronary artery disease and 9 healthy volunteers underwent dynamic cardiac SPECT with 99mTc(MIBI at rest and at pharmacological stress(test. The processing of the results included construction of the “activity–time” curves based on the identification of regions of interest in the cavity and the walls of the left ventricular (LV) myocardium. Myocardial blood flow reserve index was determined as a quotient of two ratios of mean values of counts from the myocardial area to the area under the LV cavity curve obtained in stress test and at rest. According to our data, mean value of myocardial blood flow reserve was 1.86 (1.59; 2.2) in group of healthy volunteers and 1.39 (1.12; 1.69) in patients with coronary artery disease. Cardiac dynamic SPECT(based value of myocardial blood flow reserve index <1.77 allows for identification of three-vessel coronary artery disease with sensitivity and specificity of 81.8 and 66.7%, respectively. Thus, we believe that the development of a methodology for the assessment of myocardial blood flow reserve by SPECT is a promising direction requiring further study and verification.
About the Authors
A. V. Mochula
Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, Tomsk
Russian Federation
Russian Federation
K. V. Zavadovsky
Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, Tomsk
Russian Federation
Russian Federation
S. L. Andreev
Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, Tomsk
Russian Federation
Russian Federation
Yu. B. Lishmanov
Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, Tomsk
Russian Federation
Russian Federation
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Review
For citations:
Mochula A.V., Zavadovsky K.V., Andreev S.L., Lishmanov Yu.B. RADIONUCLIDE ASSESSMENT OF MYOCARDIAL FLOW RESERVE IN PATIENTS WITH MULTIVESSEL CORONARY ARTERY DISEASE. Siberian Journal of Clinical and Experimental Medicine. 2016;31(2):31-34. (In Russ.) https://doi.org/10.29001/2073-8552-2016-31-2-31-34
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