Metabolic activity of adipose tissue depots (literature review)

O. V. Tuzovskaia; A. D. Khudiakova; Yu. I. Ragino

doi:10.29001/2073-8552-2025-771

Metabolic activity of adipose tissue depots (literature review)

O. V. Tuzovskaia, A. D. Khudiakova, Yu. I. Ragino

https://doi.org/10.29001/2073-8552-2025-771

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Abstract

Adipose tissue is attracting more and more attention of researchers from the position of an endocrine organ that implements its functions through a wide range of biomolecules called adipokines (adipocytokines). The dysfunction of adipose tissue with obesity leads to pathological secretion of these biomolecules, which causes the development of cardiovascular diseases of atherosclerotic genesis, type 2 diabetes mellitus, dyslipidemia. The review presents the latest data on the main adipose tissue depots, their cellular composition, key functions, as well as recent studies in the field of metabolic activity of adipose tissue of various localizations. PubMed and Google Scholar databases were used to search for literature. Studies conducted on patients over the age of 18 were included. The analysis did not include reviews, animal studies, drug studies, and the effects of diet and surgical treatment of obesity were not evaluated.

Keywords

adipocytokine, adipokine, obesity, adipose tissue, visceral adipose tissue, subcutaneous adipose tissue

About the Authors

O. V. Tuzovskaia

Research Institute of Therapy and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences Russian Federation (IIPM – Branch of IC&G SB RAS)
Russian Federation

Olga V. Tuzovskaia - Junior Research Scientist, Laboratory of Genetic and Environmental Determinants of the Human Life Cycle, IIPM – Branch of IC&G SB RAS.

175/1 B. Bogatkova str., Novosibirsk, 630089

A. D. Khudiakova

Alena D. Khudiakova, Cand. Sci. (Med.), Head of the Laboratory of Genetic and Environmental Determinants of the Human Life Cycle, IIPM – Branch of IC&G SB RAS.

175/1 B. Bogatkova str., Novosibirsk, 630089

Yu. I. Ragino

Yuliya I. Ragino, Dr. Sci. (Med.), Professor, Corresponding Member of the RAS, Head of the IIPM – Branch of IC&G SB RAS.

175/1 B. Bogatkova str., Novosibirsk, 630089

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Review

For citations:

Tuzovskaia O.V., Khudiakova A.D., Ragino Yu.I. Metabolic activity of adipose tissue depots (literature review). Siberian Journal of Clinical and Experimental Medicine. 2026;41(1):47-54. (In Russ.) https://doi.org/10.29001/2073-8552-2025-771

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