CLINICAL MANIFESTATIONS IN PREGNANT WOMEN WITH CHRONIC VIRAL HEPATITIS IN THE THIRD TRIMESTER AND THEIR RELATIONSHIP WITH PERFORMANCE ANXIETY

Aim. The purpose of the study was to investigate clinical manifestations in pregnant women with chronic viral hepatitis in the third trimester and their relationships with anxiety level.

Materials and Methods. A total of 169 pregnant women in the third trimester were studied. Women were divided into 2 groups: group 1 with chronic viral hepatitis (133 women) comprised pregnant women with chronic viral hepatitis В (50 women) and pregnant women with chronic viral hepatitis C (83 women); group 2 comprised 36 healthy women (control group). The groups with chronic viral hepatitis В and C were combined to form one group of pregnant women with chronic viral hepatitis.

Results. Pregnant women with chronic viral hepatitis in the third trimester showed a higher number of complaints than healthy pregnant women. The following complaints were documented: anxiety (42.11%), epigastric burning (41.36%), weakness (17.30%), etc. In healthy pregnant women, the following complaints were observed: epigastric burning, bloating, and swelling of the legs (8.34%). In pregnant women with chronic viral hepatitis, clinical manifestations were as follows: subicteric sclerae (23.31%), spider veins (21.06%), palmar erythema (72.19%), coated tongue (54.14%), etc. The level of general anxiety in pregnant women with chronic viral hepatitis was elevated and was consistent with subclinical anxiety with increases in mental, somatic, and autonomic anxiety scores (p≤0.01). In pregnant women with chronic viral hepatitis in the third trimester, the study identified the associations between a significant number of patient complaints, clinical symptoms and high anxiety score based on the Hamilton Anxiety Rating Scale.

Conclusions. In pregnant women with chronic viral hepatitis in the third trimester, the study revealed a higher number of complaints and clinical manifestations compared with those in healthy pregnant women. In pregnant women with chronic viral hepatitis in the third trimester, the total anxiety level was elevated and corresponded to subclinical anxiety score based on the Hamilton Anxiety Rating Scale. In the presence of high anxiety levels, women had a greater number of complaints and clinical symptoms.

1. Кузьмин В.Н. Специфика терапии вирусного гепатита B у беременных женщин // Справочник поликлинического врача. – 2008. – № 13. – С. 36–39.

2. О состоянии санитарно-эпидемиологического благополучия населения в Томской области в 2014 году: Государственный доклад. – М., 2015. – 168 с.

3. Учайкин В.Ф., Нисевич Н.И., Чередниченко Т.В. Вирусные гепатиты от А до ТТV у детей. – М. : Новая волна, 2003. – 432 с.

4. Куприянова, И.Е., Семке В.Я. Качество жизни – ведущая парадигма современной психиатрии // Сибирский вестник психиатрии и наркологии. – 2006. – № 1. – С. 76–78.

5. Радеева Е.В., Говорин А.В., Чистякова М.В. Тревожно-депрессивные расстройства и качество жизни больных хроническими вирусными гепатитами // Сибирский медицинский журнал (Иркутск). – 2012. – Т. 109, № 2. – С. 63–65.

6. Наmilton M. The assessment of anxiety state by rating // Br. J. Med. – 1968. – No. 8. – P. 33–37.

7. Airoldi J.A., Berghella V. Hepatitis C and pregnancy // Obstet. Gynecol. Surv. – 2006. – Vol. 61, No. 10. – P. 666–672.

8. Han G.R., Xu C.L., Zhao W. et al. Management of chronic hepatitis B in pregnancy // World J. Gastroenterol. – 2012. – Vol. 18, No. 33. – P. 4517–4521.

9. Ершова О.Н. Современные проявления эпидемического процесса гепатита С, активность естественных путей передачи, совершенствование профилактики этой инфекции: автореф. дис. … докт. мед. наук. – М., 2006. – 47 с.

10. Versace A., Bezzio S., Tovo P. Mother-to-child hepatitis C virus transmission // Hot Topics in Viral Hepatitis. – 2008. – Vol. 11. – P. 7–11.