THE ROLE OF PON 1 IN DETERMINING THE LONGXTERM PROGNOSIS IN PATIENTS WITH NON–STXELEVATION ACUTE CORONARY SYNDROME
https://doi.org/10.29001/2073-8552-2016-31-2-54-57
Abstract
Objective. The objective of the study was to examine the relationships of the paraoxonase 1 (PON1) level with the development of adverse outcomes in patients with non–ST(elevation acute coronary syndromes (NSTE(ACS) during the year of observation. Materials and Methods. The study included 75 patients with NSTE(ACS. The average age of patients in the sample was 61.1±9.5 years. Study patients comprised 31 (41.3%) men and 44 (58.6%) women. At day 10 of hospitalization, all patients produced PON1 determination in serum. Patients were divided into 2 groups: those with a favorable (n=55) and unfavorable (n=20) outcome [death from cardiovascular causes, unstable angina (UA), myocardial infarction (MI), chronic heart failure (CHF) decompensation, and acute cerebrovascular accident (CVA)]. Results. Reduction in the PON1 levels in serum to less than 4.7 ng/mL increased the risk of hospital readmission for UA during the year of observation in patients with NSTE-ACS by eight times (OR=8.3; 95% CI 1.7–42.1; p=0.002) and the risk of common adverse cardiovascular events by four times (OR=4.2; 95% CI 1.3–13.4; p=0.009). In this study, we investigated potential adverse prognostic role of PON1 in patients with NSTE(ACS. Data demonstrated that reduction in the PON1 blood levels to less than 4.7 ng/mL increased the one(year risk of an adverse outcome in patients with NSTE(ACS by four times.
About the Authors
T. A. Khomyakova
Federal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo
Russian Federation
Russian Federation
S. A. Berns
Federal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo
Russian Federation
Russian Federation
E. A. Shmidt
Federal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, Kemerovo
Russian Federation
Russian Federation
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Review
For citations:
Khomyakova T.A., Berns S.A., Shmidt E.A. THE ROLE OF PON 1 IN DETERMINING THE LONGXTERM PROGNOSIS IN PATIENTS WITH NON–STXELEVATION ACUTE CORONARY SYNDROME. Siberian Journal of Clinical and Experimental Medicine. 2016;31(2):54-57. (In Russ.) https://doi.org/10.29001/2073-8552-2016-31-2-54-57
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