Clinical case of severe aortic valve insufficiency due to ankylosing spondyloarthritis
https://doi.org/10.29001/2073-8552-2025-40-1-166-176
Abstract
Aortitis and aortic valve insufficiency are referred to as extraskeletal manifestations of ankylosing spondylitis (AS). Torpid course of diseases is the reason for late seeking medical care at the stage of irreversible changes and severe dysfunction of the cardiovascular and musculoskeletal systems. The article presents a clinical case of successful surgical treatment of severe aortic valve insufficiency in a patient with late diagnosed AS. The problems of cardiovascular pathology in AS, interdisciplinary interaction of doctors, choice of antirheumatic therapy and perioperative management of a very high cardiovascular risk patient with AS are discussed.
About the Authors
N. V. RebrovaRussian Federation
Natalya V. Rebrova, Cand. Sci. (Med.), Head of the Department of Atherosclerosis and Coronary Artery Disease
111a, Kievskaya str., Tomsk, 634012
A. S. Krapivina
Russian Federation
Anastasia S. Krapivina, Laboratory Research Assistant, Department of Atherosclerosis and Coronary Artery Disease
111a, Kievskaya str., Tomsk, 634012
N. N. Sviazova
Russian Federation
Natalia N. Sviazova, Cand. Sci. (Med.), Ultrasound Diagnostics Doctor, Junior Research Scientist, Department of Atherosclerosis and Coronary Artery Disease
111a, Kievskaya str., Tomsk, 634012
N. V. Shcherban
Russian Federation
Natalya V. Shcherban, Radiologist of X-ray Computed Tomography Room, Department of Radiology and Tomography
111a, Kievskaya str., Tomsk, 634012
I. V. Stepanov
Russian Federation
Ivan V. Stepanov, Cand. Sci. (Med.), Head of the Pathoanatomical Department
111a, Kievskaya str., Tomsk, 634012
K. S. Likhomanov
Russian Federation
Konstantin S. Likhomanov, Cand. Sci. (Med.), Cardiologist, Department of Atherosclerosis and Chronic Coronary Heart Disease
111a, Kievskaya str., Tomsk, 634012
References
1. Ward M.M. Lifetime risks of valvular heart disease and pacemaker use in patients with ankylosing spondylitis. J. Am. Heart Assoc. 2018;7:e010016. https://doi.org/10.1161/jaha.118.010016
2. Bhattad P.B., Kulkarni M., Patel P.D., Roumia M. Cardiovascular morbidity in ankylosing spondylitis: a focus on inflammatory cardiac disease. Cureus. 2022;14(6):e25633. https://doi.org/10.7759/cureus.25633
3. Navarini L., Currado D., Marino A., Di Donato S., Biaggi A., Caso F. et al. Persistence of C-reactive protein increased levels and high disease activity are predictors of cardiovascular disease in patients with axial spondyloarthritis. Sci. Rep. 2022;7(12):7498. https://doi.org/10.1038/s41598-022-11640-8
4. Lai Y., Zhang Y., Mo S. Ma J., Ni T., Lei Z. et al. Prevalence of comorbidities and risk factors in spondyloarthritis: results of a cross-sectional study. Ann. Rheum. Dis. 2022;81:e43. https://doi.org/10.1136/annrheumdis-2020-217313
5. Chetrit M., Khan M.A., Kapadia S. State of the art management of aortic valve disease in ankylosing spondylitis. Curr. Rheumatol. Rep. 2020;22(6):23. https://doi.org/10.1007/s11926-020-00898-4
6. Zhao S.S., Pittam B., Harrison N.L., Ahmed A.E., Goodson N.J., Hughes D.M. Diagnostic delay in axial spondyloarthritis: a systematic review and meta-analysis. Rheumatology (Oxford). 2021;60(4):1620– 1628. https://doi.org/10.1093/rheumatology/keaa807
7. Buleu F., Sirbu E., Caraba A., Dragan S. Heart involvement in inflammatory rheumatic diseases: a systematic literature review. Medicina (Kaunas). 2019;55(6):249. https://doi.org/10.3390/medicina55060249
8. Bolaji O., Oriaifo O., Adabale O., Dilibe A., Kuruvada K., Ouedraogo F. et al. A meta-analysis of left ventricular dysfunction in ankylosing spondylitis. J. Clin. Hypertens. (Greenwich). 2024;26(7):772–788. https://doi.org/10.3390/medicina55060249
9. Zhang M., Zhang H., Dai D., Shen B., Ruan D. Risk factors and clinical significance of ankylosing spondylitis combined with early-onset coronary heart disease. Altern. Ther. Health Med. 2024:AT10104. Online ahead of print.
10. Godzenko A.A., Korsakova Yu.O., Rumyantseva O.A., Bochkova A.G., Badokin V.V., Erdes Sh.F. Progression of aortic and valvular heart diseases in patients with ankylosing spondylitis. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2017;55(5):509– 513. (In Russ.). https://doi.org/10.14412/1995-4484-2017-509-513
11. Sherlock J.P., Joyce-Shaikh B., Turner S.P., Chao C.C., Sathe M., Grein J. et al. IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4–CD8– entheseal resident T cells. Nat. Med. 2012;18(7):1069– 1076. https://doi.org/10.1038/nm.2817
12. Reinhardt A., Yevsa T., Worbs T., Lienenklaus S., Sandrock I., Oberdörfer L. et al. Interleukin-23–dependent γ/δ T cells produce interleukin-17 and accumulate in the enthesis, aortic valve, and ciliary body in mice. Arthritis Rheumatol. 2016;68(10):2476–2486. https://doi.org/10.1002/art.39732
13. Balčiūnaitė A., Budrikis A., Rumbinaitė E., Sabaliauskienė J., Patamsytė V., Lesauskaitė V. Ankylosing spondyloarthritis resulting severe aortic insufficiency and aortitis: exacerbation of ankylosing spondyloarthritis and stenosis of the main left coronary artery after mechanical aortic valve implantation with cardiopulmonary bypass. Case Rep. Rheumatol. 2020;2020:9538527. https://doi.org/10.1155/2020/9538527
14. Huffer L.L., Furgerson J.L. Aortic root dilatation with sinus of Valsalva and coronary artery aneurysms associated with ankylosing spondylitis. Tex. Heart Inst. J. 2006;33(1):70–73.
15. Bengtsson K., Klingberg E., Deminger A., Wallberg H., Jacobsson L.T.H., Bergfeldt L. et al. Cardiac conduction disturbances in patients with ankylosing spondylitis: results from a 5-year follow-up cohort study. RMD Open. 2019;5(2):e001053. https://doi.org/10.1136/rmdopen-2019-001053
16. Fakih O., Desmarets M., Martin B., Prati C., Wendling D., Monnet E. et al. Impact of NSAIDs on 8-year cumulative incidence of major cardiovascular events in patients with ankylosing spondylitis: a nationwide study. Rheumatology (Oxford). 2023;62(10):3317–3322. https://doi.org/10.1093/rheumatology/kead072
17. Kim J.W., Yoon J.S., Park S., Kim H., Lee J.S., Choe J.Y. Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis. Ann. Rheum. Dis. 2024;83(8):1028–1033. https://doi.org/10.1136/ard-2023-225406
18. Liew J.W., Treu T., Park Y., Ferguson J.M., Rosser M.A., Ho Y.L. et al. The association of TNF inhibitor use with incident cardiovascular events in radiographic axial spondyloarthritis. Semin. Arthritis Rheum. 2024;68:152482. https://doi.org/10.1016/j.semarthrit.2024.152482
19. Genovese M.C., Mysler E., Tomita T., Papp K.A., Salvarani C., Schwartzman S. et al. Safety of ixekizumab in adult patients with plaque psoriasis, psoriatic arthritis and axial spondyloarthritis: data from 21 clinical trials. Rheumatology. 2020;59:3834–3844. https://doi.org/10.1093/rheumatology/keaa189
Review
For citations:
Rebrova N.V., Krapivina A.S., Sviazova N.N., Shcherban N.V., Stepanov I.V., Likhomanov K.S. Clinical case of severe aortic valve insufficiency due to ankylosing spondyloarthritis. Siberian Journal of Clinical and Experimental Medicine. 2025;40(1):166-176. (In Russ.) https://doi.org/10.29001/2073-8552-2025-40-1-166-176