Arterial Spin Labeling: принципы и новые тенденции в реализации метода

Цель. Изучить принципы и новые тенденции бесконтрастной магнитно-резонансной (МР) перфузии (ASL) на основе литературных данных.

Материал и методы. Проведен ретроспективный обзор рандомизированных клинических и перекрестных исследований с поиском в базах данных PUBMED, EMBASE, LILACS, SCOPUS, eLIBRARY на английском и русском языках за 2014–2024 гг. Ключевые слова, используемые для выбора статей: arterial spin labeling (ASL), pulsed ASL, continuous ASL, pseudocontinuous ASL, diffusion-prepared ASL, vessel-encoded ASL, бесконтрастная магнитно-резонансная перфузия.

Результаты. Было проанализировано 487 статей, 50 из которых использованы для составления обзора. В результате поиска созданы блоки статей, внутри которых был проведен анализ для изучения разновидностей метода ASL, технических характеристик и тенденций развития в данной области.

Заключение. Существующие разновидности ASL позволяют осуществлять выбор и учитывать преимущества и недостатки каждого метода для проведения диагностических исследований. Последовательность псевдонепрерывной маркировки спинов артериальной крови (pseudocontinuous Arterial Spin Labeling, pCASL) является наиболее изученным, надежным и доступным количественным методом, а развивающиеся перспективные технические способы сбора и обработки результатов позволят расширить применение данного метода в клинической и исследовательской практиках.

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