THE ABILITY OF AGONIST КXOPIOID RECEPTOR U-50,488 TO SIMULATE THE PHENOMENON OF ISCHEMIC POSTCONDITIONING
https://doi.org/10.29001/2073-8552-2016-31-2-107-110
Abstract
The study examined the ability of к1-opioid receptors (OR) agonist, U(50.488, in doses of 0.1 and 1 mg/kg to simulate ischemic postconditioning of the heart. Duration of ischemia was 10 or 45 min and duration of reperfusion was 10 min or 2 h. Data demonstrated that the introduction of U(50.488 in a dose of 1 mg/kg both before ischemia and 5 min before reperfusion had a pronounced antiarrhythmic effect. Injection of U-50.488 5 min before reperfusion facilitated a decrease in the ratio of infarct area/area at risk by 2 times. Antiarrhythmic effect of к-OR agonists depended on the activation of к- OR.
About the Author
A. V. Mukhomedzyanov
Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, Tomsk
Russian Federation
Russian Federation
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Review
For citations:
Mukhomedzyanov A.V. THE ABILITY OF AGONIST КXOPIOID RECEPTOR U-50,488 TO SIMULATE THE PHENOMENON OF ISCHEMIC POSTCONDITIONING. Siberian Journal of Clinical and Experimental Medicine. 2016;31(2):107-110. (In Russ.) https://doi.org/10.29001/2073-8552-2016-31-2-107-110
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