Context-specific endothelial heterogeneity (literature review)
https://doi.org/10.29001/2073-8552-2025-40-4-28-36
Abstract
The analytical review considers morphological and functional aspects of endothelial heterogeneity depending on various vascular pathologies using atherosclerosis, thrombosis, arterial hypertension and microcirculatory vasospastic angina as examples. Among the universal mechanisms of endothelial dysfunction, the most important are impaired nitric oxide biosynthesis, dysregulation of molecular mechanisms of mechanotransduction, endothelial-mesenchymal transition, proinflammatory and prothrombotic activation. Besides, the very process of physiological aging of endothelial cells in the form of increased permeability, lipid retention, adhesion and cellular transmigration is also of great importance in the pathogenesis of these diseases. Taking into account the current state of the issue of endothelial heterogeneity, promising areas for further study of its pathophysiology are briefly listed, including developments in the field of studying the transcriptome and proteome of cells of atheroprotective conduits used in coronary artery bypass grafting, and molecular-cellular analogies between oncopathology and atherosclerosis.
Supporting agencies: the study was performed within the fundamental research project No. 0419-2022-0002 “Development of innovative models for management of cardiovascular disease risk factors and comorbidities based on the study of fundamental, clinical, and epidemiological mechanisms and healthcare management techniques in the industrial region of Siberia” (Principal Investigator – Academician of the Russian Academy of Sciences O.L. Barbarash). Registration No. 122012000364-5 dated as of 20.01.2022
About the Authors
A. V. Frolov
Research Institute for Complex Issues of Cardiovascular Diseases (RI for CICVD)
Россия
Россия
Alexey V. Frolov - Dr. Sci. (Med.), Cardiovascular Surgeon, Senior Research Scientist, Laboratory of Endovascular and Reconstructive Cardiovascular Surgery, Department of Cardiovascular Surgery, RI for CICVD.
6, Barbarash Boulevard, Kemerovo, 650002
D. K. Shishkova
Research Institute for Complex Issues of Cardiovascular Diseases (RI for CICVD)
Россия
Россия
Darya K. Shishkova - Cand. Sci. (Biol.), Head of the Laboratory of Molecular, Translational and Digital Medicine, Department of Experimental Medicine, RI for CICVD.
6, Barbarash Boulevard, Kemerovo, 650002
A. G. Kutikhin
Research Institute for Complex Issues of Cardiovascular Diseases (RI for CICVD)
Россия
Россия
Anton G. Kutikhin - Dr. Sci. (Med.), Head of the Department of Experimental Medicine, RI for CICVD.
6, Barbarash Boulevard, Kemerovo, 650002
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For citations:
Frolov A.V., Shishkova D.K., Kutikhin A.G. Context-specific endothelial heterogeneity (literature review). Siberian Journal of Clinical and Experimental Medicine. 2025;40(4):28-36. (In Russ.) https://doi.org/10.29001/2073-8552-2025-40-4-28-36
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